7/25/2023 0 Comments Infographic on breast cancerNo significant differences were observed in cardiovascular outcomes, including heart failure and arterial and venous events, between statin users and nonusers. Only a small number of patients died of cardiovascular causes, and the ratios were similar between statin users and nonusers. Notably, the risk reduction was mainly attributed to cancer-related death (adjusted HR, 0.83 95% CI, 0.75-0.92 P < .001). Compared with nonusers, statin users had a significantly lower risk of all-cause death (adjusted hazard ratio, 0.83 95% CI, 0.77-0.91 P < .001). Results Overall, 7451 patients (mean age, 64.3 years) treated with statins were matched with 7451 nonusers (mean age, 65.8 years). Main Outcomes and Measures Outcomes included death, heart failure, and arterial and venous events. Interventions Patients receiving statins within 6 months before the diagnosis of breast cancer were compared with those not receiving statins. The mean (SD) follow-up duration was 4.10 (2.96) years. Statistical analyses, including Cox proportional hazards models, were performed from June 2022 to February 2023. Age, cancer stage, anticancer therapies, comorbidities, socioeconomic status, and cardiovascular drugs were matched by propensity score method. Objective To investigate the association of statin use with cancer- and noncancer-associated survival in patients with breast cancer.ĭesign, Setting and Participants This cohort study used the Taiwanese National Health Insurance Research Database and National Cancer Registry to identify patients diagnosed with breast cancer from January 2012 to December 2017. Given that patients with breast cancer in Asia are relatively younger at diagnosis and most are free from traditional cardiovascular risk factors, it is uncertain whether the use of statins can improve survival. Importance In addition to protective effects on the cardiovascular system, statins may reduce the risk of breast cancer recurrence owing to potential anti-inflammatory benefits. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography. Results of the Cumulative Incidence of Cancer Death Adjusted With Competing Risk Events of Other Reason Death Crude and Adjusted Subdistribution Hazard Ratio (sHR) of High-Dose Statin (HDS) Users, Non-HDS Users, and Statin Nonusers Among Patients With Breast CancerĮFigure 2. Crude and Adjusted Hazard Ratio (HR) of High-Dose Statin (HDS) Users, Non-HDS Users, and Statin Nonusers Among Patients With Breast CancerĮTable 8. Causes of Death Among High-Dose Statin (HDS) Users, Non-HDS Users, and Statin Nonusers Among Patients With Breast CancerĮTable 7. Baseline Characteristics of High-Dose Statin (HDS) Users, non-HDS Users, and Statin Nonusers Among Patients With Breast Cancer After Propensity Score MatchingĮTable 6. Initial Regimens of High-Dose Statins (HDS) and Non-HDSĮTable 5. Crude and Adjusted Hazard Ratio (HR) of Statin Users and Nonusers Among Patients With Breast Cancer Using Time-Dependent MethodĮTable 4. Causes of Death Between Statin Users and NonusersĮTable 3. It is vital that if you notice a lump or a change in your breast, seek immediate examination by an experienced health care professional.ETable 2. Painless, hard lumps with irregular edges are more likely to be cancer, but breast cancer may be smooth, soft or round. Men can also get breast cancer, but not nearly as much as women.Ī fresh lump is the most prominent symptom of breast cancer. The important thing is to constantly check it by yourself and remind your female loved ones. In Hong Kong, an average of 6.2 people are newly diagnosed with breast cancer every day. One in 19 women is at risk of developing breast cancer by age 75. Damage to these cells' DNA results in uncontrolled cell division and growth, and enough cells aggregate to form a lump eventually.ĭid you know breast cancer is the most common cancer among women in Hong Kong? View and play PowerPoint presentations online.īreast cancer is a disease in which cancer cells develop in the tissue of the breast.
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